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Healthy Vaginal Bacteria
Nicole Williams, MD, Chief Medical Officer for Coologics, explains the different types of vaginal bacteria and why they matter.
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Watch this video to learn more about Lactobacilus.
Background
Vulvovaginal candidiasis (VVC), caused primarily by Candida albicans, is treated with anti-fungal drugs, often with variable efficacy and relapses. New therapeutic strategies, including drug-free alternatives, are needed. Upon overgrowth or environmental triggers, C. albicans commensal yeast transitions into hyphae resulting in an aberrant immunopathologic neutrophil response that contributes to the characteristic signs and symptoms of vaginitis. The purpose of this study was to evaluate the efficacy of an intravaginal cooling device (Vlisse) in women with VVC to provide symptom relief via putative reversal of C. albicans hyphae to yeast, with additional proof of principle in an animal model.
Importance of Mouse Data
*ALL drugs tested in the mouse model FAILED due to pH, favoring infection
Two studies in mice (2018) were conducted at LSU (PhD Experts in VVC) Results establish:
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The mechanism of action
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Proof of cooling efficacy
Results
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Statistically Significant reduction in inflammation (PMNs) or white blood cells: the immune response
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Statistically Significant reduction in infection (Hyphae)
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‘p‘ values less than 0.05 are statistically significant